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PDE5 Inhibitors

PDE5 Inhibitors

We are now so much busy with day-to-day work. We have hardly any time left for ourselves. With changing lifestyles, there come many diseases. One such disease is related to sex where men are unable to hold an erection for a longer time during sexual intercourse with their partner. It not only humiliates them in front of their counterpart but hampers their sexual and personal life as well. But with advancements in science, many pharmaceutical companies are come up with a solution. One such invention is PDE5 inhibitors

In this article, we will give you a little overview of PDE5 inhibitors. 

About PDE5 inhibitors

Erectile dysfunction is treated with PDE5 inhibitors, a class of medications for treating such sexual disorders. Phosphodiesterase 5 inhibitors were first found as a treatment for excessive blood pressure and angina. However, it was discovered by mistake by a reliable source, Pfizer, for treating erectile dysfunction. It is thought to be among the most effective treatments for sexual dysfunction in men of all ages.

More than 60 million persons are estimated to cope with sexual difficulties over the world. This condition used to affect only aged men, but with changing lifestyles, it is now affecting teenage as well. PDE5 inhibitors are commonly used to treat erectile dysfunction symptoms, which are related to the less amount of blood supply to the penis.

Working on Phosphodiesterase 5 inhibitors 

PDE5 inhibitors work directly on the penis, allowing the blood vessels to relax. It increases blood flow in the area, allowing for erection.

Erection is a complicated technique. The nerve system around the penile region becomes excited while you are sexually active. This process causes the release of a chemical known as nitric oxide (NO). The presence of an unknown amount of nitric oxide enhances the exposure to another molecule known as cyclic GMP. This chemical aids in the relaxation of blood vessel muscle and improves blood flow in the penis region by nearly 40 percent.

Phosphodiesterase 5 inhibitors aid in the breakdown of cyclic GMP molecules and the inversion of the erection process. They have a structure that is similar to cyclic GMP, which prevents PDE5 inhibitors from breaking down. The action of nitric oxide, which helps the circulation of blood in the penis, was boosted as a result of this treatment.

Adverse effects of PDE5 inhibitors

Every medicine has some negative effects, but the intensity depends upon the condition of the body. Some like Headache, flushing, indigestion, vision problems, back discomfort, and muscle soreness are some of the most prevalent side effects.

Categories of PDE5 inhibitors


Sildenafil Citrate:

Sildenafil, marketed as Viagra, was the first widely used PDE5 inhibitor to be licensed by the FDA in 1998. Doctors give it to individuals who suffer from erectile dysfunction. It normally takes an hour for its effects to be visible on the body. The effects of Viagra continue for roughly 4 hours. The recommended daily dosage ranges from 25 mg to 200 mg.

Some Popular Sildenafil Tablets

Kamagra 100 | Kamagra Oral jelly | Cenforce 100 | Cenforce 200 | Fildena 100


It is a drug that is used to treat erectile (Cialis). Tadalafil was first introduced to the market in 2003 to treat erectile dysfunction. It normally takes about 20 minutes to demonstrate its action. It should be consumed at least 25min before sexual intercourse. The FDA has also given permission to prescribe this inhibitor as a treatment for Benign Prostate Hyperplasia (BPH). In Phosphodiesterase 5 inhibitors, tadalafil had the longest action. The daily dose of tadalafil ranges from 2.5 to 80 mg.

Some Popular Tadalafil Tablets

Vidalista 20 | Vidalista 40 | Vidalista 60 | Tadalista


Vardenafil was also licensed for the treatment of erectile dysfunction in 2003. This has the fastest effect of any PDE5 inhibitor, taking only 10 minutes to demonstrate results. Verdenafil has a typical duration of 6 to 8 hours. Vardenafil PDE5 inhibitors come in doses ranging from 5 to 20 mg per day.

Always take proper advice from your doctor before consuming any medicine.

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